Relationships between cognitive complaints and objective cognitive scores in cancer: metamemory evaluation

Coordinator: Giffard B

Background: Many studies have reported the absence of a significant correlation between neuropsychological test performance and subjective patient complaints after adjuvant treatment. Patient perception of cognitive deficits is generally lower than what is measured by neuropsychological tests. The reason for this apparent absence of relationship is probably multifactorial and related to the: 1) methodology, 2) psycho-affective status (anxiety/depression and fatigue) and 3) metacognition, often evaluated in some diseases to better understand the impact on cognitive impairment. However, it has never been investigated in cancer patients. Currently,this is ahighly sensitive measurement to evaluate the patient perception and to understand patient complaints, and its relationship with real cognitive performances. Objectives: Evaluation of metamemory (patient estimation of their own memory capacity), patient memory complaints and real memory performance in cancer patients and comparison with paired healthy control subjects.

Study methodology: Controlled case studies: the performances of 60 patients will be compared with those of 30 healthy volunteers

Current study status: Closed, 60 patients and 30 healthy volunteers have been included

Collaboration: INSERM U1077 unit

Publication :

Giffard B, Perrotin A, Allain P, Dayan J, Eustache F, Grellard JM, Faveyrial A, Joly F, Lange M. The role of metamemory on cognitive complaints in cancer
patients. Brain Behav. 2020 Mar 10:e01545. doi: 10.1002/brb3.1545. [Epub ahead of print] PubMed PMID: 32154659.