Program of rehabilitation to improve cognitive alterations reported by the patients : randomized and multicentric study

Coordinator: A. Capel, J. Lefel

Background: There are frequent reports on the detrimental impact of chemotherapy on patients’ cognitive functions (memory, concentration or attention deficits), whether objective as measured by cognitive tests or subjective as revealed through patient perception. There is mounting evidence that chemotherapy leads to a negative impact on the quality of life of these patients. Despite this observation and the increasing number of patients complaining of such modifications, there are no current specific treatments for these disorders. Thus, the use of therapeutic methods such as cognitive rehabilitation adapted to the complaints of cancer patients could mitigate this reported “cognitive fog” or “chemofog” and thereby improve patients’ quality of life.

Objectives: Evaluate treated cancer patients complaining of cognitive disturbances and the benefit of cognitive rehabilitation workshops on the perceived cognitive function and quality of life.

Study methodology: Ongoing randomised study comparing three groups: the test group (RehaCom® exercises), control group 1 (exercises at home) and control group 2 (standardized phone call follow-ups).

Current study status: Closed, 168 patients enrolled.

Collaboration: Four participating centers

Sponsor: Ligue Nationale contre le Cancer


Dos Santos M, Hardy-Léger I, Rigal O, Licaj I, Dauchy S, Levy C, Noal S, Segura C, Delcambre C, Allouache D, Parzy A, Barriere J, Petit T, Lange M, Capel A, Clarisse B, Grellard JM, Lefel J, Joly F. Cognitive rehabilitation program to improve cognition of cancer patients treated with chemotherapy: A 3-arm randomized trial. Cancer. 2020 Sep 30. doi: 10.1002/cncr.33186. Epub ahead of print. PMID: 32996583.