Impact of cognitive functions on observance in patients with oral cancer therapies

Coordinator: F. Joly

Background: Oral treatment compliance has been studied mainly in the context of chronic diseases, such as diabetes, HIV and cardiovascular diseases. This research has improved the understanding of the factors influencing treatment compliance. However, in oncology, the compliance issue with the recent development of oral treatments has not been deeply examined and thus the impact of initial cognitive function of patients on oral treatment compliance has never been assessed. This study will improve the understanding of the factors that influence compliance (including initial cognitive function) and will allow a better identification of patients who are more likely to comply with oral treatment. This project fits into an implementation approach for an adaptated therapeutic education.

Objectives: Evaluate the links between cognitive functions and the introduction of an oral anti-cancer treatment and the compliance with this treatment.

Study methodology: Monocenter pilot study

Current study status: Closed, 129 patients enrolled

Collaboration: /

Sponsor: Ligue régionale contre le Cancer, Groupe Pasteur Mutualisé

Publications :

  • Dos Santos M, Lange M, Gervais R, Clarisse B, Capel A, Barillet M, Grellard JM, Heutte N, Licaj I, Joly F. Impact of anxio-depressive symptoms and cognitive function on oral anticancer therapies adherence.  Support Care Cancer. 2019 Jan 28. doi: 10.1007/s00520-019-4644-4. [Epub ahead of print] PubMed PMID: 30690685.