Impact of chemotherapy on cognitive function in an animal behavioural model: Investigation of brain mechanisms associated with behavioural flexibility in young and aged subjects.

Coordinator: Castel, H

Background: Cognitive disorders in patients are multifactorial and can be exacerbated in elderly cancer patients. The evaluation of the role of a single chemotherapy in young and old cancer-free animals with an intact emotional status reveals the direct role of the molecule on brain function and demonstrates the “risk” factor associated with ageing.

Objectives: Evaluation of 5-Fluorouracil on cognitive functions several weeks after treatment completion in young and aged mice.

Study methodology: Behavioural tests in C57B/L6 mice, intraperitoneal chemotherapy injections and neurobiological analyses on brain samples.

Current study status: closed

Collaboration: PsyNCA and F. Baclesse

Sponsor: Cancéropole Nord-Ouest


Chemotherapy-induced long-term alteration of executive functions and hippocampal cell proliferation: role of glucose as adjuvant. Dubois M, Lapinte N, Villier V, Lecointre C, Roy V, Tonon MC, Gandolfo P, Joly F, Hilber P, Castel H. Neuropharmacology. 2014 Apr;79:234-48.