Impact of adjuvant chemotherapy on the cognitive function and quality of life of patients over the age of 65 years: application to breast cancer.

Coordinator : F.Joly, M. Lange

Background: The overall increase in life expectancy and the improvement in the management of elderly cancer patients allow them to live longer in better conditions. Breast cancers are among the most frequent cancers in people over the age of 65. The prognosis of this disease has improved due to several types of curative treatments (surgery, radiation therapy and chemotherapy). The alteration of the patient’s quality of life induced by chemotherapy depends on the patient age, especially if side effects concern cognitive functions.

Objectives: Evaluate the incidence and evolution of the cognitive impairment caused by chemotherapy in patients over the age of 65 receiving adjuvant treatment for breast cancer.

Study methodology: A non-randomised, multicenter, longitudinal study comparing a group of patients receiving adjuvant chemotherapy with a group of patients receiving only radiation treatment . The patient inclusion phase is now complete and 123 patients have been enrolled.

Current study status: Inclusion phase closed. Study under way.

Collaboration: Three participating centers.

Sponsors: PHRC, Institut National du cancer (INCA), Cancéropole Nord-Ouest (CNO), Sanofi-Aventis

Publications :

  • Small BJ, Lange M, Zhai W, Ahn J, Ahles TA, Carroll JE, Cohen HJ, Graham D, Extermann M, Heutte N, Jim HSL, McDonald BC, Patel SK, Root JC, Saykin AJ, Van Dyk K, Zhou X, Mandelblatt J, Joly F. Thinking Living with Cancer C. O. G.-Age Studies. Impact of taxane-based chemotherapy among older women with breast cancer on cognition and quality of life: a longitudinal pooled analysis. Breast Cancer Res Treat. 2021 Nov 24. doi: 10.1007/s10549-021-06455-6. Epub ahead of print. PMID: 34817750.
  • Lange M, Heutte N, Noal S, Rigal O, Kurtz JE, Lévy C, Allouache D, Rieux C, Lefel J, Clarisse B, Leconte A, Veyret C, Barthélémy P, Longato N, Tron L, Castel H, Eustache F, Giffard B, Joly F. Cognitive Changes After Adjuvant Treatment in Older Adults with Early-Stage Breast Cancer.  The Oncologist. 2018 Jun 22. pii: theoncologist.2017-0570. doi: 10.1634/theoncologist.2017-0570. [Epub ahead of print] PubMed PMID: 29934409.
  • Lange M., Heutte N., Rigal O., Noal S., Kurtz J-E., Lévy C., Allouache D., Rieux C., Lefel J., Clarisse B., Veyret C., Barthélémy P., Longato N., Eustache F., Giffard B., Joly F. Decline in cognitive function in older adults with early-stage breast cancer after adjuvant treatment. The Oncologist. 2016 Jul 29 ; 21, 1337-1348.
  • Lange M., Giffard, B., Noal, S., Rigal, O., Kurtz, J-E., Heutte, N., Lévy, C., Allouache, D., Rieux, C., Lefel, J., Daireaux, A., Clarisse, B., Veyret, C., Barthélémy, P., Longato, N., Eustache, F., Joly, F. Baseline cognitive functions among elderly patients with localized breast cancer. Eur J Cancer. 2014 Sep;50(13):2181-9