Impact of cancer on functional memory: improving the understanding of impairment using neuropsychological approaches and neuroimaging (project supplementary to Cog-Age).

Coordinator: Joly F, Giffard B

Background: The real impact of chemotherapy on cognitive function, especially memory, has not been thoroughly studied. Previous studies, which aimed to better describe memory deficits, are too descriptive and the pathophysiological mechanisms involved in these deficits have not yet been identified.

Objectives: The primary objective is to assess the relationship between memory deficits and brain dysfunction in patients receiving adjuvant chemotherapy for breast cancer (before and after treatment) by comparing them with a group of healthy subjects. Study methodology: Longitudinal review of neuropsychological and neuroimaging case studies with 30 subjects and 30 controls. Evaluation of memory impairment by analysing response time and/or identification scores and/or the number of correct responses. Brain dysfunction will be evaluated using grey matter and white matter density (determined through anatomical MRI) as well as tests at rest and under activation (functional MRI).

Current study status: Inclusion phase closed. Study under way.

Collaboration: Unité INSERM U1077

Sponsor: 2011 Rose Ribbon award, Cancéropôle Nord-Ouest, Ligue Nationale Contre le Cancer and Ligue du Calvados Contre le Cancer, INCa SHS

Publications :

Perrier J, Viard A, Levy C, Morel N, Allouache D, Noal S, Joly F, Eustache F, Giffard B. Longitudinal investigation of cognitive deficits in breast cancer patients and their gray matter correlates: impact of education level. Brain Imaging Behav. 2018 Nov 7. doi: 10.1007/s11682-018-9991-0. [Epub ahead of print] PubMed PMID: 30406352.

Morel N., Dayan J., Piolino P., Viard A., Allouache D., Noal S., Levy C., Joly F., Eustache F., Giffard B. Emotional specificities of autobiographical memory after breast cancer diagnosis. Consciousness and Cognition 2015 Sept ; 35, 42-52.

Giffard B, Viard A, Dayan J, Morel N, Joly F, Eustache F. Autobiographical memory, self, and stress-related psychiatric disorders: which implications in cancer patients? Neuropsychol Rev. 2013 Jun;23(2):157-68